Member information

Find more information on the members of the Marine Natural Product Laboratory

Brad Haltli

Research Interests:
My research is focused on the discovery of novel bioactive natural products from marine microorganisms. Within this field I am interested in the biology, diversity and biogeography of prokaryotes from marine habitats. I am particularly interested in bacteria beloning to the bacterial class Actinomycetales. I am also interested in the genetic and biochemical processes involved in the production of natural products in marine microorganisms. In the Kerr research group I am responsible for directing mirobiology (bacteria)-related aspects of student projects.
Bachelor of Science, University College of the Cariboo (Thompson Rivers University), Kamloops, BC, Canada (1998).
Master of Science, Dalhousie University, Halifax, NS, Canada (2001)
Work Experience:
Research Scientist 1, Wyeth Research, Natural Products Discovery Research.  Pearl River, NY, USA, (2001-2008)
Research Manager, University of Prince Edward Island, Kerr Marine Natural Products Laboratory, Charlottetown, PE, Canada (2008 - )
Bacterial NP Discovery Group Leader, Nautilus Biosciences Canada Inc, Charlottetown, PE, Canada (2009-)
Peer-reviewed Publications

1.      Tangerina M.P., Correa H., Haltli B., Vilegas W., Kerr R.G. Bioprospecting from cultivable bacterial communities of marine sediment and invertebrates from the underexplored Ubatuba region of Brazil. Arch Microbiol. 2017 199: 155-169.
2.      McCauley E.P., Haltli B., Correa H., Kerr R.G. Spatial and temporal investigation of the microbiome of the Caribbean octocoral Erythropodium  caribaeorum. FEMS Micro Ecol. 2016 92: pii: fiw147. doi: 10.1093/femsec/fiw147.
3.      Robertson V.*, Haltli B.*, Overy D., Kerr R.G. Highly variable bacterial communities associated with the octocoral Antillogorgia elisabethae. Microorganisms 2016 4: pii:E23. doi: 10.3390/microorganisms 4030023.
4.      Pastrana-Camacho N., Suárez Z., Acosta-González A., Arango C., Haltli B., Correa H., Kerr R.G., Duque C., Diaz L.E. Bioprospecting for culturable actinobacteria with antimicrobial properties isolated from rivers in Colombian Orinoquia. Trop J Pharm Res. 2016 15: 1259-1265.
5.      Sommer B., Overy D.P., Haltli B., Kerr R.G. Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities. Microbiology 2016 162: 1069-79.
6.      Herzog B., Overy D.P., Haltli B., Kerr R.G. Discovery of keratinases using bacteria isolated from marine environments. Syst Appl Microbiol. 2016 39: 49-57.
7.       Arens J.C., Haltli B., Kerr R.G. Draft Genome Sequence of Kitasatospora griseola Strain MF730-N6, a Bafilomycin, Terpentecin, and Satosporin Producer. Genome Announc. 2015  3: e00208-15.
8.      McCauley E.P., Haltli B., Kerr R.G. Description of Pseudobacteriovorax antillogorgiicola gen. nov., sp. nov., a bacterium isolated from the gorgonian octocoral Antillogorgia elisabethae, belonging to the family Pseudobacteriovoracaceae fam. nov., within the order Bdellovibrionales. Int J Syst Evol Microbiol. 2015 65: 522-30.
9.      Duncan K.R., Haltli B., Gill K.A., Correa H., Berrué F., Kerr R.G. Exploring the diversity and metabolic potential of actinomycetes from temperate marine sediments from Newfoundland, Canada. J Ind Microbiol Biotechnol. 2015 42: 57-72.
10.    Janso J.E., Haltli B.A., Eustáquio A.S., Kulowski K., Waldman A.J., Zha L., Nakamura H., Bernan V.S., He H., Carter G.T., Koehn F.E., Balskus E.P. Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica. Tetrahedron. 2014 70: 4156-4164.
11.    Duncan K., Haltli B., Gill K. A., Kerr R.G. Bioprospecting from marine sediments of New Brunswick, Canada: exploring the relationship between total bacterial diversity and Actinobacteria diversity. Mar Drugs. 2014 12: 899-925.
12.    Correa H., Haltli B., Duque C., Kerr R.G. Bacterial communities of the gorgonian octocoral   Pseudopterogorgia elisabethae Microb Ecol. 2013 66: 972-85.
13.    Pike R.E., Haltli B., Kerr R. G. Description of Endozoicomonas euniceicola sp. nov. and Endozoicomonas gorgoniicola sp. nov., bacteria isolated from the octocorals Eunicea fusca and Plexaura sp., and an emended description of the genus Endozoicomona.  Int J Syst Evol Microbiol. 2013 63: 4294-4302.
14.    McCulloch M. W. B., Haltli B., Marchbank D. H., Kerr R. G. Evaluation of pseudopteroxazole and pseudopterosin derivatives against Mycobacterium tuberculosis and other pathogens. Mar Drugs. 2012 10: 1711-1728.
15.    McCulloch M.W.B., Berrue F., Haltli B., Kerr R.G. One-pot syntheses of pseudopteroxazoles from pseudopterosins: a rapid route to non-natural congeners with improved antimicrobial activity. J Nat Prod. 2011 74: 2250-2256.
16.    Jiang H., Haltli B., Feng X., Cai P., Summers M., Lotvin J., He M. Investigation of the biosynthesis of the pipecolate moiety of neuroprotective polyketide meridamycin. J Antibiot 2011 64: 533-538.
17.    Berrue F., Withers S. T., Haltli B., Withers J., Kerr R.G.  Chemical screening method for the rapid identification of microbial sources of marine invertebrate-associated metabolites.  Mar Drugs. 2011 9:  369-381.
18.    Liu H., Jiang H, Haltli B., Kulowski K., Muszynska E., Feng X., Summers M., Young M., Graziani E., Koehn F., Carter G. T., Min H.  Rapid cloning and heterologous expression of the meridamycin biosynthetic gene cluster using a versatile Escherichia coli-Streptomyces artificial chromosome vector, pSBAC. J Nat Prod. 2009 72 (3): 389-395.
19.    Ratnayake A. S., Haltli B., Feng X., Bernan V. S., Singh M. P., He H., Carter G.T.  Investigating the biosynthetic origin of the nitro group in pyrrolomycins. J Nat Prod. 2008 71 :  1923–1926.
20.    He M., Haltli B., Summers M., Feng X., Hucul J.A.  Isolation and characterization of the meridamycin biosynthetic gene cluster from Streptomyces species NRRL 30748.  Gene. 2006 377: 109-118.

21.   Magarvey N. A., Haltli B., He M., Greenstein M. and Hucul J.A.  Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens. Antimicrob Agents Chemother. 2006 50: 2167-2177.

22.   Haltli B., Tan Y., Magarvey N.A., Wagenaar M., Yin X., Greenstein M., Hucul J.A., Zabriskie T.M. Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins. Chem Biol. 2005 12(11): 1163-1168. 
23.   Ritacco F. V., Haltli  B., Janso J. E., Greenstein M., Bernan V.S.  Dereplication of Streptomyces soil isolates and detection of specific biosynthetic genes using an automated Ribotyping instrument. J Ind Microbiol Biotechnol. 2003 30: 472-479.


Stacey Kerr

Research Interests:
Lab Manager responsibilities include: managing budgets, general
administrative tasks, ordering of scientific equipment and lab supplies,
overseeing the lab scientific diving program and coordinating collection
expeditions.  I am also an active scientific diver.
BSc (honors) in Chemistry
Florida Atlantic University
BA  in Psychology
Boston College

Work Experience:


David Overy

Research Interests:

Acting in a lead role in the Fungal Natural Products Group focused upon the isolation and characterization of fungal strains accessioned into the Marine Natural Products Bank and the fermentation and generation of fungal culture extracts.  Research initiatives include the development of innovative methodologies for fungal isolation and the application of molecular biology tools and various biological assays used to predict the production of novel metabolites and enzymes of interest.  The fungal natural products group is focused upon the discovery of novel antimicrobial compounds, biosurfactants and bioemulsifiers, novel peptides and enzymes for a variety of pharmaceutical, nutraceutical, agricultural and personal care product applications.



PhD, Technical University of Denmark, Kgs. Lyngby, Denmark(2005)
MSc(equivalency), Technical University of Denmark, Kgs. Lyngby, Denmark (2001)
BScHigh Honours in Environmental ScienceCarleton University, Ottawa, Canada (1999)


Work Experience:

Adjunct Professor, Department of Pathology and Microbiology, Atlantic Veterinary College, University of PEI (2014 - present)
Senior Research Scientist – Fungal NP Discovery Group LeaderNautilus Bioscience Canada Inc. (2009 - present)
Research Manager, Chemistry Department, University of Prince Edward Island (Dec. 2008 - present)
Senior Research Microbiologist, CIBE, Merck Research Laboratories, Merck, Sharp & Dohme de España, Madrid, Spain. (Apr 07 – Oct 2008)
Postdoctoral Researcher, Institute of Biological Sciences, University of Wales, Aberystwyth, UK. (Aug 05 - Apr 07)
Postdoctoral Researcher, Mycology Group, CMB, BioCentrum-DTU, Lyngby, Denmark.(Apr 05 - Jul 05)
PhD student, Mycology Group, CMB, BioCentrum-DTU, Lyngby, Denmark. (Jan 02 - Apr 05)
Researcher, Dept. of Chemistry, University of Canterbury, Christchurch, New Zealand.(Oct 03 - May 04)
Researcher/Sole Proprietor, Myco-Botanical Technologies, Oakville, Ontario, Canada.(Apr 00 - Jan 02)
Diagnostician, Plant Protection Service, Wageningen, Netherlands. (Jul 00 - Nov 00; Mar 01 - Sept 01)
Contract Researcher, ECORC, Agriculture and Agri-Food Canada, Central Experimental Farm, Ottawa, Canada. (June 99 - Mar 00)
Honours Thesis, ECORC, Agriculture and Agri-Food Canada, Ottawa, Canada. (Sept 98 - May 99)
Student Researcher, ECORC, Agriculture and Agri-Food Canada, Ottawa, Canada. (May 98 - Sept. 98)



Overy DP, Martin C, Muckle A, Lund L, Wood J, Hanna P.  2015.  Cutaneous phaeophyphomycosis caused by Exophiala attenuata in a domestic cat.  Mycopathologia, 180:281-287.

Overy DP, Marron-Lopez F, Muckle A, Bourque A, Lund L, MacHattie D, Lopez A.  2015. Dermatophytosis in farmed mink (Mustela vison) caused by Trichophyton equinum.  Journal of Veterinary Diagnostic Investigation, 27:621-626.

Overy DP, Groman D, Giles J, Duffy S, Rommens M, Johnson G.  2015.  Exophiala angulospora causes systemic mycosis in Atlantic halibut (Hippoglossus hippoglossus): a case report.  Journal of Aquatic Animal Health, 27: 12-19.

Sommer B, Overy DP, Kerr RG.  2015.  Identification and characterization of lipases from Malassezia restricta, a causative agent of dandruffFEMS Yeast Research, 15: fov078.

Herzog B, Overy DP, Haltli B, Kerr RG.  2015.  Discovery of keratinases using bacteria isolated from marine environmentsSystematic and Applied Microbiology,

Abd-El-Aziz AS, Agatemor C, Etkin N, Overy DP, Kerr RG.  2015.  Redox-active cationic organoiron complex: a promising lead structure for developing antimicrobial agents with activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.  RSC Advances, 5: 86421-86427.

Abd-El-Aziz AS, Agatemor C, Etkin N, Overy DP, Lanteigne M, McQuillan K, Kerr RG.  2015.  Antimicrobial organometallic dendrimers with tunable activity against multidrug-resistant bacteria.  Biomacromolecules, 16: 3694-3703.

Overy, D.P., Bayman, P., Kerr, R.G., Bills, G.F.  2014.  An assessment of natural products discovery from marine (sensu strictu) and marine-derived fungi.  Mycology, in press.

Overy, D.P., Berrue, F., Correa, H., Hanif, N., Hay, K., Lanteigne, M., McQuilian, K., Duffy, S., Boland, P., Jagannathan, R., Carr, G.S., Vansteeland, M., Kerr, R.G.  2014.  Sea foam as a source of fungal inoculum for the isolation of biologically active natural products.  Mycology, in press.

Overy, D.P., Groman, D., Giles, J., Duffy, S., Johnson, G.  2014.  Exophiala angulospora causes systemic mycosis in Atlantic halibut (Hippoglossus hippoglossus) – A case report.  J. Aquat. Anim. Health, accepted.

Khankhet, J., Vanderwolf, K.J., McAlpine, D.F., McBurney, S., Overy, D.P., Slavic, D., Xu, J.  2014.  Clonal expansion of the Pseudogymnoascus destructans genotype in North America is accompanied by significant variation in phenotypic expression. PLOS ONE, accepted.

Marchal, E., Uddin, Md.I., Smithen, D.A., Hawco, L.A., Lanteigne, M., Overy, D.P., Kerr, R.G., Thompson, A.  2013.  Antimicrobial activity of non-natural prodigiosenes.  RSC Advances, 3: 22967-22971.

Ebead, G.A., Overy, D.P., Berrue, F., Kerr, R.G. 2012. Westerdykella reniformis sp. nov., producing the antibiotic metabolites melinacidin IV and chetracin BIMA Fungus3: 189-201.

Houbraken, J., Frisvad, J.C., Siefert, K.A., Overy, D.P., Tuthill, D.M., Valdez, J.G., Samson, R.A. 2012. New penicillin-producing Penicillium species and an overview of section ChrysogenaPersoonia29: 78-100.

Pelaez, F., Collado, J., Platas, G., Overy, D.P., Martin, J., Vicente, F., Gonzalez del Val, A., Basilio, A., De la Cruz, M., Tormo, J.R., Fillola, A., Arenal, F., Villareal, M., Rubio, V., Baral, H.O., Galan, R., Bills, G.F. 2011. Phylogeny and intercontinental distribution of the pneumocandin-producing anamorphic fungus Glarea lozoyensisMycology2: 1-17.

Beckmann, M., Enot, D.P., Overy, D.P., Scott, I., Jones, P., Allaway, D., and Draper, J.  2010. Metabolite fingerprinting of urine suggests breed-specific dietary metabolism differences in domestic dogs.  British Journal of Nutrition103:1127-1138.

Overy, D.P., Calati, K., Nielsen Kahn, J., Hsu, M., Martin, J., Collado, J., Roemer, T., Harris, G., Parish, C. 2009. Isolation and structure elucidation of parnafungins C and D, isoxazolidinone-containing antifungal natural productsBioorganic & Medicinal Chemistry Letters19: 1224-1227.
Bills, G.F., Platas, G., Overy, D.P., Collado, J., Fillola, A., Jimenez, M.R., Martin, J., Gonzalez del Val, A., Vicente, F., Tormo, J.R., Pelaez, F., Calati, K., Harris, G., Parish, C., Xu, D., Roemer, T. 2009. Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungiMycologia101: 445-468.
Bills, G.F., Overy, D.P., Genilloud, O. and Peláez, F. 2009. Contributions of pharmaceutical antibiotic and secondary metabolite discovery to the understanding of microbial defence and antagonism. In: Defensive Mutualism in Microbial Symbiosis. Editors J. White and M.S. Torres, Marcel Dekker, New York. (in press)
Overy, D.P., Enot, D.P., Tailliart, K., Jenkins, H., Parker, D., Beckmann, M. and Draper, J. 2008. Explanatory signal interpretation and metabolite identification strategies for nominal mass FIE-MS metabolite fingerprintsNature Protocols3: 471-485.
Enot, D.P., Wanchang, L., Beckmann, M., Parker, D., Overy, D.P. and Draper, J. 2008.  Preprocessing, classification modelling and feature selection using flow injection elcetrospray mass spectrometry metabolite fingerprint dataNature Protocols3: 446-470.
Parker, D., Beckmann, M., Enot, D.P., Overy, D.P., Caracuel Rios, Z., Gilbert, M., Talbot, N. and Draper, J. 2008.  Rice blast infection of Brachypodium distachyon as a model system to study dynamic host/pathogen interactionsNature Protocols3: 435-445.
Beckmann, M., Enot, D.P., Overy, D.P. and Draper, J. 2007. Representation, comparison, and interpretation of metabolome fingerprint data for total composition analysis and quality trait investigation in potato cultivars. Journal of Agricultural and Food Chemistry55: 3444-3451.
Enot, D.P., Beckmann, M., Overy. D.P., Draper, J. 2006. Predicting interpretability of metabolome models based on behavior, putative identity, and biological relevance of explanatory signals. Proceedings of the National Academy of Science, USA.103:14865-14870.
Overy, D.P., Smedsgaard, J., Frisvad, J.C. and Thrane, U. 2006. Host-derived media used as a predictor for low abundant, in planta metabolite production from necrotrophic fungi.  Journal of Applied Microbiology101: 1292-1300.
Overy, D.P., Phipps, R., Frydenvang, K. and Larsen,T.O. 2006. epi-Neoxaline, a chemotaxonomic marker for Penicillium tulipaeBiochemical Systematics and Ecology34: 345-348.
Frisvad, J.C., Larsen, T.O., Dalsgaard, P.W., Lyhne, E.K., Jarvis, B.B., Fettinger, J.C., Seifert, K.A., Louis-seize, G. and Overy, D.P. 2006. Four psychrotolerant species with high chemical diversity consistently producing cycloaspeptide, Penicillium jamesonlandense sp. nov., P. ribeum sp. nov, P. soppii and P. lanosumInternational Journal of Systematic and Evolutionary Microbiology56: 1427-1437.
Valdez, J.G., Makuch, M.A., Ordovini, A.F., Masuelli, R.W., Overy, D.P. and Piccolo,R.J. 2006. Penicillium allii, responsible for blue mold rot in garlic in the Mendoza and San Juan provinces of Argentina. Plant Disease55: 583.
Valdez, J.G., Makuch, M.A., Ordovini, A.F., Masuelli, R.W., Overy, D.P. and Piccolo,R.J. 2006. First report of Penicillium allii as a field pathogen of garlic (Allium sativum)Plant Pathology55: 583.
Overy, D.P. and Frisvad, J.C. 2005. Mycotoxin production and post harvest storage rot of Zingiber officinale by Pencillium brevicompactumJournal of Food Protection68:607-609.
Overy, D.P., Frisvad, J.C., Steinmeier, U. and Thrane, U. 2005. Clarification of the agents causing blue mould storage rot upon various flower and vegetable bulbs: implications for mycotoxin contaminationPostharvest Biology and Technology35: 217-221.
Overy, D.P., Karlshøj, K. and Due, M.J. 2005. Temperature and enzymatic profiling of taxa from the Penicillium series Corymbifera; species responsible for blue mould storage rot in bulbs.  Journal of Plant Pathology87: 53-59.
Overy, D.P., Larsen, T.O., Dalsgaard, P.W., Frydenvang, K., Phipps, R., Monro, M and Christopherson, C. 2005. Andrastin A and barceloneic metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implicationsMycological Research11: 1243-1249.
Overy, D.P., Nielsen, K.F. and Smedsgaard, J. 2005. Roquefortine/oxaline biosynthesis pathway metabolites in Penicillium ser. Corymbiferain planta production and implications for competitive fitness. Journal of Chemical Ecology31: 2375-2392.
Overy, D.P., Valdez, J.G. and Frisvad, J.C. 2005. Revisions to the Penicillium series Corymbifera: agents responsible for blue mold storage rot of various flower and vegetable bulbs.  Canadian Journal of Botany83: 1422-1433.
Overy, D.P., Zidorn, C.H.W., Petersen, B.O., Duus, J.Ø., Dalsgaard, P.W., Larsen, T.O. and Phipps, R. 2005. Medium dependant production of corymbiferone, a novel metabolite from Penicillium hordei cultured on plant tissue agarTetrahedron Letters46: 3225-3228.
Overy, D.P. and Blunt, J.W. 2004. Corymbiferan lactones from Penicillium hordei: stimulation of novel phenolic metabolites using plant tissue media. Journal of Natural Products67: 1850-1853.
Overy, D.P. and Frisvad, J.C. 2003. New Penicillium species associated with bulbs and root vegetables. Systematic and Applied Microbiology 26: 631-639.
Overy, D.P, Seifert, K., Savard, M.E., Frisvad, J.C. 2003. Spoilage fungi and their mycotoxins in commercially marketed chestnuts. International Journal of Food Microbiology 88: 69-77.

Hebelin Correa

Research Interests:
My postdoctoral research project is to identify new antimicrobial and cytotoxic compounds from Actinomycetes. The overall approach is to ferment microbes from the Nautilus library, extract cultures and conduct an assay-guided purification. The structures of active purified compounds are elucidated using LC-HRMS and NMR methods.
PhD in Marine Natural Products
Universidad Nacional de Colombia,Colombia & University of Prince Edward Island (PE)
MSc in Chemistry
Universidad Nacional de Colombia, Colombia
BSc in Chemistry
Universidad Nacional de Colombia, Colombia
Work Experience:


Bastian Herzog

Research Interests:

Keratinases are enzymes with the ability to degrade keratin, the main structural protein of hair and skin. My work focuses on the identification of a keratinase being highly specific for hair and skin keratin that might be applicable to soften/remove hair and as active ingredient in anti-aging products. Environmental samples as well as known bacteria strains are screened for their keratin biodegradation, characterized and purified.


• 2004 – 2009 Studies in biology at the University of Regensburg, focus on microbiology

Work Experience:

• 2010 – 2013 Scientific worker / PhD student, Chair of Urban Water Systems Engineering, Technical University of Munich

• 2010 Internship, GeneArt AG, Regensburg


• Herzog, B., et al., Effect of acclimation and nutrient supply on 5-tolyltriazole biodegradation with activated sludge communities. Bioresource Technology, 2014. 

• Yuan, H., Herzog, B., et al., Determination of optimal conditions for 5-methyl-benzotriazole  biodegradation with activated sludge communities by dilution of the inoculum. Science of The Total Environment, 2014. 487: p. 756-762. 

• Herzog, B., et al., Xenobiotic benzotriazoles—biodegradation under meso- and oligotrophic conditions as well as denitrifying, sulfate-reducing, and anaerobic conditions. Environmental Science and Pollution Research, 2014. 21(4): p. 2795-2804. 

• Herzog, B., et al., Screening and monitoring microbial xenobiotics’ biodegradation by rapid, inexpensive and easy to perform microplate UV-absorbance measurements. BMC Research Notes, 2014. 7(1): p. 101. 

• Herzog, B., et al., Monitoring benzotriazoles: a 1 year study on concentrations and removal efficiencies in three different wastewater treatment plants. Water Science & Technology, 2014. 69(4): p. 710-717. 

• Herzog, B., et al., Characterization of pure cultures isolated from sulfamethoxazole-acclimated activated sludge with respect to taxonomic identification and sulfamethoxazole biodegradation potential. BMC microbiology, 2013. 13(1): p. 276. 

• Herzog, B., et al., Analysis and in situ characterization of activated sludge communities capable of benzotriazole biodegradation. Environmental Sciences Europe C7 - 31, 2013. 25(1): p. 1-8. 

• Herzog, B. and R. Wirth, Swimming behavior of selected species of Archaea. Applied and environmental microbiology, 2012. 78(6): p. 1670-1674. 

• Wirth, R., et al., The mode of cell wall growth in selected archaea is similar to the general mode of cell wall growth in bacteria as revealed by fluorescent dye analysis. Applied and environmental microbiology, 2011. 77(5): p. 1556-1562.

Bettina Sommer

Research Interests:
Many Malassezia species are part of the cutaneous microflora commonly found on animals and human. Their presence is often associated with skin disorders, e.g. dandruff and seborrheic dermatitis. Unique for most of the Malassezia species is a lipid-dependency, which can be tracked back on the absence of a fatty acid synthase. Therefore, specific inhibitors for Malassezia lipases are thought to be extremely effective against these organisms.
The project aims to find the natural substrate of the lipases as well as their inhibitors, which are of high value for personal care products as they might be an effective supplement in anti-dandruff formulations.
November 2009 University of Regensburg Graduation with diploma (Dipl.-Biol.)

February 2009 – November 2009 Institute of Biophysics and Physical Biochemistry

Diploma thesis “Activation of a chimeric RNA polymerase subunit using directed evolution”

August 2004 – November 2009 Studies in biology at the University of Regensburg. Main focus on biochemistry 


Work Experience:

December 2013 Technische Universität München Graduation to Dr. rer. nat.

December 2009 – January 2014 Dissertation „A new synthetic biology methodology for the cell-free production of industrial alcohols” doctoral candidate, Industrial Biocatalysis and Chemistry of Biogenic Resources, Technische Universitaet Muenchen


1, Sommer B, Waege I, Pöllmann D, Seitz T, Thomm M, et al. 2014, Activation of a Chimeric Rpb5/RpoH Subunit Using Library Selection. PLoS ONE 9(1): e87485. doi:10.1371/journal.pone.0087485

2, Sommer B, Garbe D, Schrepfer P, Brück T. 2013. Characterization of a highly thermostable ß-hydroxybutyryl CoA dehydrogenase from Clostridium acetobutylicum ATCC 824. Journal of Molecular Catalysis B: Enzymatic 98: 138-144

3, Sommer B, Haack M, Garbe D, Brück T. 2013. Catalytic Modules in Non-Natural Butanol Biosynthesis: Conversion of the Key Intermediate Crotylalcohol to n-Butanol via a Designed Enzyme Cascade. JSM Biotechnol Bioeng 1(2): 1010

4, Guterl JK, Garbe D, Carsten J, Steffler F, Sommer B, Reisse S, Philipp A, Haack M, Rühmann B, Koltermann A, Kettling U, Brück T, Sieber V.2012. Cell-free metabolic engineering: production of chemicals by minimized reaction cascades. ChemSusChem 5:2165-2172.

Logan MacIntyre

Research Interests:







Work Experience:

Stacey Goldberg

Research Interests:

Advancement of molecular methods for identification of bromotyrosine alkaloid derivatives from marine sponges and assessment of their therapeutic potential.
Marine sponges provide unique and diverse niches for microbial communities, where bacterial symbionts can account for up to 60% of the mesohyl biomass. Since habitat diversity typically correlates with microbial diversity and in turn, chemical diversity, it is not surprising that marine sponges are known for their rich arsenal of bioactive secondary metabolites. A high percentage of these metabolites belong to an interesting family of brominated tyrosine derived alkaloids that display antimicrobial and cytotoxic properties. There is increasing evidence that the symbiotic microbes are the true producers of these secondary metabolites, rather than the invertebrate host. Since a great majority of sponge microbes do not remain viable in culture, access to their secondary metabolites is limited. Thus, new approaches are needed to address this major obstacle of sustainably fermenting bioactive metabolites. The objective of this research is to assess the microbial diversity of selected marine sponges and determine the ability of sponge-associated microbes to produce brominated bioactive compounds. This will be accomplished by combining conventional methods with novel molecular-based approaches to study key genes involved in the biosynthesis of brominated compounds. The origin of the genes will then provide evidence to determine the biosynthetic producers of these brominated bioactive metabolites.
Ph.D. University of Prince Edward Island, Canada  (Sept 2012 - Current)
Biomedical Sciences, Marine Natural Products
M.S. Johns Hopkins University, Maryland  (Sept 2002-Sept 2005)
B.S. Towson University, Maryland  (Sept 1996-Dec 2000)
Biology with Chemistry minor


Work Experience:
Bermuda Institute of Ocean Sciences, St. George’s, Bermuda
Phytoplankton Ecology Lab – Marine Particle Imaging Lab
Research Technician (Jul 2010 –May 2012)
Responsibilities: Managed the Flow Cytometry Facility (MARPIL), through which every project in the Phytoplankton Ecology Lab (and other labs) was executed. In less than 2 years, became an expert in operating and troubleshooting the BD Influx flow cytometer and cell sorter and developed optimal efficiency for completing enumeration and 90-99% pure sorting of oceanic samples (phytoplankton, heterotrophic bacteria, and eukaryotes). As a Scientist on the R/V HSBC Atlantic Explorer (research vessel), executed Conductivity, Temperature, Depth (CTD) deployment, stable isotope incubations, and filtrations of ocean water samples. Solely responsible for converting MARPIL into a mobile ‘at sea’ lab on cruises lasting 5 – 17 days, for a total of 2 months at sea. This accomplishment placed me in a category of one of a few other scientists in the world who have been able to achieve a fully functioning flow lab at sea.
Meso-Scale Discovery, Maryland
Critical Reagents Group
Research Associate (Jan 2009-Jul 2010)
Responsibilities: Contributed to the development of sandwich based ELISA “type” assays, utilizing MSD proprietary Electro-chemiluminescence (ECL) and multi-array technologies, which are used by research laboratories and drug development companies around the world to analyze disease states through the characterization and quantification of biomarkers. Responsible for assessing and optimizing the critical reagents used to develop MSD assays that provided highly sensitive, quantified, reproducible results. Maintained inventory, proper handling and storage of critical reagents utilized for assays. •
Aeras Global TB Vaccine Foundation, Maryland
Immunology Vaccine Assessment Group
Research Specialist (Dec 2005-Dec 2008)
Responsibilities: Supervised the Vaccine Assessment group devoted to assessment of Tuberculosis vaccine studies using a variety of in vitro immunoassays, and executed analysis of multi-color flow cytometry data. Focused on looking for poly-functionality of cells and correlations with protection of TB. Successfully accelerated the validation and qualification of human Intracellular cytokine assay for use in Pre-clinical and Phase I clinical trials according to GLP regulations, and was responsible for writing qualified standard operating procedures (SOP) required for maintaining quality control of the assays.
Johns Hopkins University, Maryland
Cancer Research Department
Senior Lab Technician Jun 2002-Dec 2005
Responsibilities: Supported clinical oncology trials for AML/CML, Multiple Myeloma, and Hodgkins Lymphoma, where patients received GM-CSF producing vaccines. Processed clinical blood samples using density-gradient centrifugation (ficoll), isolated plasma and PBMC’s, and used cells in a variety of assays to assess immune response to vaccines.

Goldberg S., Mueller S., Brichetti J., Sadoff J. Cryo-preserved Whole Blood (WB) for use in Cell Mediated Immunity (CMI) Assays, Poster on behalf of Aeras Global TB Vaccine Foundation. TB Vaccines for the World Conference, Atlanta, GA (2008).

Casey, J.R., Aucan J.P., Goldberg S.R., Lomas M.W. Changes in partitioning of carbon amongst autotrophic pico- and nanoplankton groups in response to changes in the North Atlantic Oscillation. Deep Sea Research II: Topical Studies in Oceanography (Feb 2013).

Goldberg, S. Advancement of molecular methods for identification of bromotyrosine alkaloid derivatives from marine sponges and assessment of their therapeutic potential. Graduate Studies and Research Days, AVC, University of Prince Edward Island (2013). Gold Prize Award.

Alyssa Grunwald

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Work Experience:

Erin McCauley

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Work Experience:

Hope Igboeli

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Nadia Prigoda-Lee

Research Interests:

2014-Present  Atlantic Veterinary College, UPEI, PE, Canada 
PhD Student, Department of Biomedical Sciences

2002-2004  University of Guelph, ON, Canada - MSc Botany
Thesis: Molecular and phenotypic expression of Aly-13 in Arabidopsis lyrata
Supervisor: Dr. Barbara Mable

1995-1999  McMaster University, ON, Canada - Hons. BSc Life Sciences
Thesis: Effect of black pepper extract on Giardia lamblia
Supervisor: Dr. George Sorger

Work Experience:

2012-2014  Impact Genetics Inc., ON, Canada
Research and Development Supervisor

2004-2012  Solutions by Sequence, ON, Canada
Laboratory Technician

2002-2003  University of Guelph, ON, Canada
Teaching Assistant

1999-2001  Visible Genetics Inc., ON, Canada
Research and Development Laboratory Technician

Selected Publications:

Identification of clinically relevant mosaicism in type I hereditary haemorrhagic telangiectasia
Prigoda-Lee NL, Matevski D, Dumitru D, Piovesan B, Rushlow D, Gallie BL.
J Med Genet. 2011 May; 48(5):353-7.

Retinoblastoma: the evidence does matter
Prigoda-Lee NL, Rushlow D, Piovesan B, Zhang K, Dimaras H, Pajovic S, Gallie BL.
Cell Oncol. 2009;31(3):249-50.

Hereditary haemorrhagic telangiectasia: mutation detection, test sensitivity and novel mutations
Prigoda NL, Savas S, Abdalla SA, Piovesan B, Rushlow D, Vandezande K, Zhang E, Ozcelik H, Gallie BL, Letarte M.
J Med Genet. 2006 Sep;43(9):722-8.

Phenotypic and genotypic expression of self-incompatibility haplotypes in Arabidopsis lyrata suggests unique origin of alleles in different dominance classes
Prigoda NL
, Nassuth A, Mable BK.
Mol Biol Evol. 2005 Jul;22(7):1609-20. Epub 2005 Apr 27.


Amanda Thomas

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Amanda Sproule

Research Interests:
2014-Present   University of Prince Edward Island, PE, Canada
MSc. Molecular and Macromolecular Sciences

2010-2014  University of Guelph, ON, Canada
BSc. Honours Chemistry with Distinction

Work Experience:

2013-2014  University of Guelph, ON, Canada
Undergraduate research assistant with Dr. W. Tam - synthetic organic chemistry and natural product isolations

2013-2014 University of Guelph, ON, Canada
Undergraduate lab volunteer and fourth year thesis project with Dr. F.-I. Auzanneau - carbohydrate synthesis


Doug Marchbank

Research Interests:
My research is primarily focused on the discovery and development of natural products with a range of applications in human health and wellness. Our team utilizes a LC/MS-based metabolomics approach to profile microbial extracts and identify potentially novel compounds through statistical analysis. This work also includes purification and structure elucidation of natural products and characterization of their properties. My efforts are also focused on the synthesis of natural product analogues to expand our knowledge of structure-activity relationships and develop new lead compounds. As a senior chemist with Nautilus Biosciences, I am interested in the development of organic UV filters, biosurfactants, antimicrobials, and antioxidants.
PhD, University of Prince Edward Island (2013)
BSc (Hons) in Chemistry, University of Prince Edward Island (2008)
Work Experience:
Research Manager, Chemistry Department, University of Prince Edward Island (2015 - present)
Senior Scientist, Nautilus Biosciences Canada Inc., Charlottetown, PE, Canada (2015 - present)
Research Assistant, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada (2014 - 2015)
Postdoctoral Fellow, University of Prince Edward Island (2013)
McCulloch, M.W.B.; Haltli, B.H.; Marchbank, D.H.; Kerr, R.G. Evaluation of pseudopteroxazole and pseudopterosin derivatives against Mycobacterium tuberculosis and other pathogens. Mar. Drugs 2012, 10, 1711-1728.
Marchbank, D.H.; Berrue, F.; Kerr, R.G. Eunicidiol, an anti-inflammatory dilophol diterpene from Eunicea fusca. J. Nat. Prod. 2012, 75, 1289-1293.
Marchbank, D.H.; Kerr, R.G. Semisynthesis of fuscoside B analogues and eunicosides, and analysis of anti-inflammatory activity. Tetrahedron 2011, 67, 3053-3061.

Leon Liang

Research Interests:
Secondly metabolite induction of microbial; biological screening methods; Organic synthesis.

2011-2013 Chemical Engineering, Hainan University

2013-present (transfer) Chemistry(Undergraduate), UPEI

Work Experience:
CHEN Da, JIA Chun-man, ZHANG Chun-yan, ZHANG Qi, CAO Li, SUN Lu, LIANG Li-bang. Synthesis of γ-Nitro Ester Compounds by Solvent-free Ball-milling Method[J]. Fine Chemicals, 2014, 31(1): 124-128.

Nick Mulligan

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Owen Leger

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Martin Lanteigne

Research Interests:

Planning, running, troubleshooting and quality control for a panel of different types of whole cell-based assays including bacterial and fungal (bio-safety level 1 and 2 human pathogen (10-15 organisms)). 

-Screening our extract library for antimicrobial compound. After completion of the assays, the results are calculated, analyzed and distributed to recipients followed by archival of the data in a digital laboratory repository.

Developing new high-throughput assays for screening purposes.  

-Working on a project that needs a high-throughput assay to screen for Y enzymes for X number of organisms in Z amount of time.

-As well as work on a biofilm disruption assay for the screening of compounds that could disrupt the formation or already formed biofilms. 

BSc in Biochemistry
University of Moncton, Moncton, NB (2004-2007)
2- year diploma in biotechnology
CCNB (New Brunswick Community College) Edmunston, NB (2002-2004)
Work Experience:
Microbiologist research assistant in the Kerr Lab, Charlottetown, PE (2009-present)
Bio-molecular research assistant, University of Prince Edward, PE (2007 - 2009)
Co-op training,  ACRI (Atlantic Cancer Research Institute) Moncton, NB (summer 2004 - summer 2005)

1. E.Marchal, Md. I. Uddin, D. A. Smithen, C. L. A. Hawco, M. Lanteigne, D. P. Overy, R. G. Kerr and A. Thompson. Antimicrobial activity of non-natural prodigiosenes. RSC Advances 2013, 3, 22967–22971

2. David P. Overy, Fabrice Berrue, Hebelin Correa, Novriyandi Hanif, Kathryn Hay, Martin Lanteigne, Kathrine Mquiliana, Stephanie Duffy, Patricia Boland, Ramesh Jagannathan, Gavin S. Carr, Marieke Vansteeland and Russell G. Kerr*.Sea foam as a source of fungal inoculum for the isolation of biologically active natural products. Mycology, 2014.

Maritime natural product conference: Antimicrobial screening of a library of extracts from marine invertebrates
Seminar: Anti-Cancer treatment Targeting BCL-2 family using SiRNA