Marine Natural Products Lab

Kerr Research Group
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Fabrice Berrué

Tue, 06/09/2015 - 10:12 -- Patricia Boland
Research Interests:
 
Discovery and development of marine-derived natural products with applications in human health and wellness.
  • Isolation, purification, and  structure elucidation of natural products.
  • Evaluation of biological and physical properties of purified metabolites
Development of fast and robust tools for the  secondary metabolome exploration of microbial extracts using LC-HRMS anlyses combined with statistical analyses (PCA, cluster analysis).
  • Chemical dereplication of  bacteria according to their metabolic profiling using LC-HRMS and statistical analysis.
  • Investigation of innovative methodologies to induce the production of silent natural products
Management of the laboratory analytical platform including two LC-HRMS instruments (Exactive and LTQ-Orbitrap Velos), LCMS directed fraction collector system,  three LC semi-preparative systems and a GC-MS.
  • Validation of new analytical methods to characterize quantitatively and qualitatively bioactive compounds and crude extracts.
  • Development of innovative strategies for the fractionation and purification of natural products.

Developement in partenership with Nautilus Biosciences of a wide range of natural products with personal care application such as small chemical entities with UV protective activity, antidandruff agents, biosurfactants and surface active metabolites and secreted small proteins and polysaccharides.

 
Education:
 
PhD degree in bioorganic chemistry, Nice, France (2005)
M. Phil. in organic chemistry, University of Manchester, UK. (2000)
Diploma from the National Institute of chemistry of Montpellier, France (2000)
 
Work Experience:
 
2010-present
Senior Scientist, Nautilus Biosciences Canada Inc (part time)
 
2007-present
Research Manager (management of the chemistry section)
Laboratory of Prof. Kerr, University of Prince Edward Island, Canada.
 
2005-2006 
ATER, Nice 
Half-time: Assistant professor. Course in organic chemistry (Master level).
Half-time: Research project in biomimetic synthesis of bioactive polyketides.
2002-2005
Laboratory of bioorganic chemistry, Nice, France.
PhD on “Isolation of new compounds with antitumoral activity from marine sponges” realised in the research group of Dr Philippe Amade.
2001
CAFAC, Lille, France.  
Product manager, from design phase to marketing, on high value technical rubber products.
Management of customers from Paris and the around area.
1999-2000
Laboratory of Prof. Sutherland, University of Manchester, England.
Study and synthesis of cephalosporin derivatives by a semi synthetic pathway.
1999
Institut de Ciència de Materials de Barcelona, Spain. (2 month) 
Elaboration of new ligands for the synthesis of organometallic compounds.
 
Publications:
  • Markus, M.A.; Ferrier, J.; Luchsinger, S.M.; Yuk, J.; Cuerrier, A.; Balick, M.J.; Hicks, J.M.; Killday, K.B.; Kirby, C.W.; Berrué, F.; Kerr, R.G.; Knagge, K.; Gödecke, T.; Ramirez, B.E.; Lankin, D.C.; Pauli, G.F.; Burton, I.; Karakach, T.K.; Arnason, J.T.; Colson, K.L. Distinguishing vaccinium species by chemical fingerprinting based on NMR spectra, validated with spectra collected in different laboratories. Planta Med. 2014, 80, 732-739.
  • Gill, K.A.; .Berrué, F.; Arens, J.C.; Kerr, R.G. Isolation and Structure Elucidation of Cystargamide, a Lipopeptide from Kitasatospora cystarginea. J. Nat. Prod. 2014, 77, 1372-1376.
  • Carr, G.; Berrue, F.; Klaiklay, S.; Pelletier, I.; Landry, M.; Kerr, R. G. Natural products with protein tyrosine phosphatase inhibitory activity. Methods 2014, 65, 229-238.
  • Van den Heuvel, M. R.; Hogan, N. S.; MacDonald, G. Z.; Berrue, F.; Young, R. F.; Arens, C. J.; Kerr, R. G.; Fedorak, P. M. Accumulation and biliary excretion of naphthenic acids in yellow perch exposed to oil sands-affected waters. Chemosphere 2014, 95, 619-627.
  • Berrue, F.; Forner, D.; Correa, H.; Duncan, K.; Kerr, R. G. Chemical dereplication of marine actinomycetes by liquid chromatography – high resolution mass spectrometry profiling and statistical analysis. Anal. Chim. Acta. 2013, 805, 70-79.
  • Berrue, F.; Arens, J. C.; Pearson, J. K.; Kerr, R. G. Isolation and Structure Elucidation of Satosporin A and B: New Polyketides from Kitasatospora griseola. Org. Lett. 2013, 15, 3864-3867.
  • Berrue F.; McCulloch, M. W. B.; Boland, P.; Hart S.; Harper M. K., Johnston J.; Kerr, R. G. Isolation of Steroidal Glycosides from the Caribbean Sponge Pandaros acanthifolium. J. Nat. Prod. 2012, 75, 2094-2012.
  •  Ebead G. A.; Overy D. P.; Berrue, F.; Kerr, R. G. Westerdykella reniformis sp. nov., producing the antibiotic metabolites melinacidin IV and chetracin B. IMA fungus. 2012, 3, 189-201.
  •  Marchbank, D. H.; Berrue, F.; Kerr, R. G. Eunicidiol, an Anti-inflammatory Dilophol Diterpene from Eunicea fusca. J. Nat. Prod. 2012, 75, 1289-1293.
  •  Berrue, F.; McCulloch, M. W. B.; Kerr, R. G. Marine diterpene glycosides. Bioorg. Med. Chem. 2011, 19, 6702-6719.
  • McCulloch, M. W. B.; Berrue, F.; Haltli, B.; Kerr, R. G. One-Pot Syntheses of Pseudopteroxazoles from Pseudopterosins: A Rapid Route to Non-natural Congeners with Improved Antimicrobial Activity. J. Nat. Prod. 2011, 74, 2250-2256.
  • Berrue, F.; Withers, S. T.; Haltli, B.; Withers, J.; Kerr, R. G. Chemical screening method for the rapid identification of microbial sources of marine invertebrate-associated metabolites. Mar. Drugs 2011, 9, 369-381.
  • Berrue, F.; Kerr, R. G. Diterpenes from Gorgonian Corals. Nat. Prod. Rep. 2009, 26, 681-710.
  •  Laville, R.; Thomas, O. P.; Berrue, F.; Marquez, D.; Vacelet, J.; Amade, P. Bioactive Guanidine Alkaloids from two Caribbean Marine Sponges. J. Nat. Prod. 2009, 72, 1589-1594.
  • Berrue, F.; Ibrahim, A.; Boland, P.; Kerr, R. G. Newly Isolated Marine Bacillus Pumilus (SP21): A Source of Novel Lipoamides and Other Antimicrobial Agents. Pure Appl. Chem. 2009, 81, 1027-1031.
  •  Laville, R.; Thomas, O. P.; Berrue, F.; Reyes, F.; Amade, P. Pachychalines A-C: Novel 3-Alkylpyridinium Salts from the Marine Sponge Pachychalina Sp. Eur. J. Org. Chem. 2008, 121-125.
  •  Berrue, F.; Antoniotti, S.; Thomas, O. P.; Amade, P. Bioinspired Metal-Catalyzed Doebner-Knoevenagel Condensations between Malonic Acid Half Thioesters and Aldehydes. Eur. J. Org. Chem. 2007, 1743-1748.
  • Berrue, F.; Thomas, O. P.; Laville, R.; Prado, S.; Golebiowski, J.; Fernandez, R.; Amade, P. The Marine Sponge Plakortis Zyggompha: A Source of Original Bioactive Polyketides. Tetrahedron 2007, 63, 2328-2334.
  • Berrue, F.; Thomas, O. P.; Fernandez, R.; Amade, P. Iso-, nor-, and Dinor-Spiculoic Acids A, Polyketides from the Marine Sponge Plakortis Zyggompha. J. Nat. Prod. 2005, 68, 547-549.
  • Berrue, F.; Thomas, O. P.; Funel-Le Bon, C.; Reyes, F.; Amade, P. New Bioactive Cyclic Peroxides from the Caribbean Marine Sponge Plakortis Zyggompha. Tetrahedron 2005, 61, 11843-11849.
  •  Funel-Le Bon, C.; Berrue, F.; Thomas, O. P.; Reyes, F.; Amade, P. Sodwanone S, a Triterpene from the Marine Sponge Axinella Weltneri. J. Nat. Prod. 2005, 68, 1284-1287.
  • Martin, M. J.; Berrue, F.; Amade, P.; Fernandez, R.; Francesch, A.; Reyes, F.; Cuevas, C. Halogenated Helianane Derivatives from the Sponge Spirastrella Hartmani. J. Nat. Prod. 2005, 68, 1554-1555.
  • Funel, C.; Berrue, F.; Roussakis, C.; Rodriguez, R. F.; Amade, P. New Cytotoxic Steroids from the Indian Ocean Sponge Axinella Cf. Bidderi. J. Nat. Prod. 2004, 67, 491-494.