Fabrice Berrue

Research Interests:
 
Drug discovery program focussed on marine invertebrates and microorganisms: Biological & chemical screening, extraction, assay-guided fractionation, purification and characterization of bioactive secondary metabolites.Extensive study on secondary metabolites present in the gorgonian Erythropodium caribaeorum (EC): Compound inventory mainly focused on terpenoids which could be involved in eleutherobin biosynthesis.Chemical screening of EC bacterial community to reveal the bacterial origin for secondary metabolites previously isolated from the coral. The presence of eleutherobin and related compounds is our main objective.
 
Education:
 
PhD degree in bioorganic chemistry, Nice, France (2005)
M. Phil. in organic chemistry, University of Manchester, UK. (2000)
Diploma from the National Institute of chemistry of Montpellier, France (2000)
 
Work Experience:
 
2007-
Laboratory of Prof. Kerr, University of Prince Edward Island, Canada.
Marine Natural Product Chemist. Research Manager.
2005-2006 
ATER, Nice 
Half-time: Assistant professor. Course in organic chemistry (Master level).
Half-time: Research project in biomimetic synthesis of bioactive polyketides.
2002-2005
Laboratory of bioorganic chemistry, Nice, France.
PhD on “Isolation of new compounds with antitumoral activity from marine sponges” realised in the research group of Dr Philippe Amade.
2001
CAFAC, Lille, France.  
Product manager, from design phase to marketing, on high value technical rubber products.
Management of customers from Paris and the around area.
1999-2000
Laboratory of Prof. Sutherland, University of Manchester, England.
Study and synthesis of cephalosporin derivatives by a semi synthetic pathway.
1999
Institut de Ciència de Materials de Barcelona, Spain. (2 month) 
Elaboration of new ligands for the synthesis of organometallic compounds.
 
Publications:
 
Berrue, F.; Kerr, R. G. Diterpenes from Gorgonian Corals. Nat. Prod. Rep. 2009, 26, 681-710.
 
Laville, R.; Thomas, O. P.; Berrue, F.; Reyes, F.; Amade, P. Pachychalines A-C: Novel 3-Alkylpyridinium Salts from the Marine Sponge Pachychalina Sp. Eur.J.Org.Chem.; European Journal of Organic Chemistry 2008, 121-125.
 
Berrue, F.; Antoniotti, S.; Thomas, O. P.; Amade, P. Bioinspired Metal-Catalyzed Doebner-Knoevenagel Condensations between Malonic Acid Half Thioesters and Aldehydes. Eur.J.Org.Chem.; European Journal of Organic Chemistry 2007, 1743-1748.

Berrue, F.; Thomas, O. P.; Laville, R.; Prado, S.; Golebiowski, J.; Fernandez, R.; Amade, P. The Marine Sponge Plakortis Zyggompha: A Source of Original Bioactive Polyketides. Tetrahedron 2007, 63, 2328-2334.
 
Berrue, F.; Thomas, O. P.; Funel-Le Bon, C.; Reyes, F.; Amade, P. New Bioactive Cyclic Peroxides from the Caribbean Marine Sponge Plakortis Zyggompha. Tetrahedron 2005, 61, 11843-11849.

Berrue, F.; Thomas, O. P.; Fernandez, R.; Amade, P. Iso-, nor-, and Dinor-Spiculoic Acids A, Polyketides from the Marine Sponge Plakortis Zyggompha. J. Nat. Prod. 2005, 68, 547-549.
 
Martin, M. J.; Berrue, F.; Amade, P.; Fernandez, R.; Francesch, A.; Reyes, F.; Cuevas, C. Halogenated Helianane Derivatives from the Sponge Spirastrella Hartmani. J. Nat. Prod. 2005, 68, 1554-1555. 

Funel, C.; Berrue, F.; Roussakis, C.; Rodriguez, R. F.; Amade, P. New Cytotoxic Steroids from the Indian Ocean Sponge Axinella Cf. Bidderi. J. Nat. Prod. 2004, 67, 491-494.
 
Funel-Le Bon, C.; Berrue, F.; Thomas, O. P.; Reyes, F.; Amade, P. Sodwanone S, a Triterpene from the Marine Sponge Axinella Weltneri. J. Nat. Prod. 2005, 68, 1284-1287.