Newly isolated marine Bacillus pumilus (SP21): a source of novel lipoamides and other antimicrobial agents

Newly isolated marine Bacillus pumilus (SP21): a source of novel lipoamides and other antimicrobial agents

Berrue, Fabrice; Ibrahim, Abdelnasser; Boland, Patricia; Kerr, Russell G.

A screening of marine bacteria for antimicrobial activity resulted in the isolation of Bacillus pumilus (SP21) from a sediment sample collected in the Bahamas.  A bioassay-guided fractionation led to the isolation of five surfactin analogs, glycocholic acid, amicoumacins A and B in addn. to three new compds. named lipoamides A-C.  The chem. structure of all the bioactive compds. was elucidated using spectroscopic methods including 2D NMR and MS.  The antimicrobial activity of each compd. was evaluated against a panel of pathogens and is reported herein.

Pure and Applied Chemistry, Volume 81, Issue 6 Pages 1027-1031