Research Interests:
Discovery and development of novel bioactive compounds produced by fungi isolated from the marine environment: cultures, extractions, purification and characterization. Chemical dereplication through metabolomic tools
Education:
PhD in Marine Natural Products (2011)
Laboratoire Mer Molécules Santé (EA2160), Université de Nantes, France
PharmD (2008)
Université de Nantes, France
Master degree in Biological and Medical Sciences (2007)
Université de Nantes, France
Work Experience:
2012 - 2013
Post-doctoral fellow
“Search for pancreatic lipase inhibitors from marine microorganisms”
“Exploration of the secondary metabolome of fungi using metabolomics tools and an epigenetic approach”
Nautilus Biosciences Canada Inc.
2011-2012
ATER (teaching and research assistant) in Pharmacognosy
“Production of communesins, cytotoxic alkaloids from a marine-derived strain of Penicillium expansum”
Faculté de Pharmacie/Laboratoire Mer Molécules Santé (EA2160), Université de Nantes, France
2010-2011
Project manager assistant (2010-2011, 9 monthes)
“Natural extracts screening for antitumoral activity”
Atlantic Bone Screen, Nantes, France
2007-2011
PhD in Marine Natural Products
“Fungal metabolites from marine environment: isolation and characterization of antiproliferative compounds produced by Penicillium spp.” Laboratoire Mer Molécules Santé (EA2160), Université de Nantes, France
2005-2006
Non-resident pharmacy student
Hôpital Laennec, Nantes, France / Hôpital Saint-Jacques, Nantes, France
Iowa Methodist Medical Center, DesMoines (Iowa), USA / Iowa Heart Center, DesMoines (Iowa), USA.
2005 (1 month)
“Phenolic acid and flavonoid aglycone analyses by GC/MS, spectrophotometry and antioxidant bioassay”
Division of pharmaceutical biology, Faculty of pharmacy, University of Helsinki, Finland
Publications:
Carroux A., Van Bohemen A.-I., Roullier C., Robiou du Pont T., Vansteelandt M., Bondon A., Zalouk-Vergnoux A., Pouchus Y. F., Ruiz N., Unprecedented 17-residue peptaibiotics produced by marine-derived Trichoderma atroviride. Chemistry and Biodiversity, 2013, 10(5), 772-786.
Vansteelandt, M., Blanchet E., Egorov M., Petit F., Toupet L., Bondon A., Monteau F., Le Bizec B., Thomas O. P., Pouchus Y. F., Le Bot R., Grovel O., Ligerin, an antiproliferative chlorinated sesquiterpenoid from a marine-derived Penicillium strain. Journal of Natural Products, 2013, 76(2), 297-301.
Vansteelandt M., Kerzaon I., Blanchet E., Fossi Tankoua O., Robiou du Pont T., Joubert Y., Monteau F., Le Bizec B., Frisvad J.C., Pouchus Y.F., Grovel O., Patulin and secondary metabolite production by marine-derived Penicillium strains. Fungal Biology, 2012, 116(9), 954-961.
Ruiz N., Petit K., Vansteelandt M., Kerzaon I., Baudet J., Amzil Z., Biard J.-F., Grovel O., Pouchus Y.F., Enhancement of domoic acid neurotoxicity on Diptera larvae bioassay by marine fungal metabolites. Toxicon, 2010, 55(4), 805-810.
Patent
Egorov M.,* Le Bot R.,* Petit F.,* Grovel O.,* Pouchus Y. F.,* Vansteelandt M.,* Preparation of fumagillol derivatives useful for the treatment or prevention of bone tumors. Fr. Demande FR 2973376 A1 20121005, PCT Int.Appl. WO 2012130906 A1 20121004, 2012.
