Marine Natural Products Lab

Kerr Research Group
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Chris Cartmell

Wed, 08/07/2019 - 10:28 -- Jen MacPhail

Research Interests:

I am a driven natural product chemist with a strong interest in mass spectrometry and the discovery and development of new bioactive natural products and their analogues from both marine and terrestrial sources. Completing my BSc at the University of Bangor in north Wales, an area of outstanding natural beauty, cultivated my interest for natural products which lead to my PhD studies at the University of St Andrews under the supervision of Professor Rebecca Goss. My current research focuses on identification, isolation, and structural elucidation of novel natural products along with the development of accessing silent or cryptic biosynthetic pathways.

Education:

2015 - 2019PhD Chemistry, University of St Andrews, Scotland, United Kindgom

2012 - 2015 - BSc Chemistry, University of Bangor, Wales, United Kingdom

Publications: 

Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions. Y. Renault, R. Lynch, E. Marelli, S. V. Sharma, J. Sharp, C. Cartmell, P. Cárdenas,  R. J. M. Goss., Chem. Commun., 2019 accepted.

Diversification through Heck cross-coupling of indole based substrates in H2O: from unprotected halotryptophans to halotryptophans in a natural and a new to nature natural product.  C. Pubill-Ulldemolins,S. V. Sarma,  C. Cartmell,J. Zhao, P. Cárdenas,  R. J. M. Goss.,*Chem. Eur. J., 2019, 25.

Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo. S. V. Sharma, X. Tong, C. Pubill-Ulldemolins, C. Cartmell, R. J. M. Goss et al, Nat. Commun., 2017, 8.

Sonogashira diversification of unprotected halotryptophans, halotryptophans containing tripeptides and generation of a new to nature bromo-natural product and its diversification in water. M. Corr, S. V. Shama, C. Cartmell, R. J. M. Goss et al., Chem. Sci., 2017, 8, 2039-2046

Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. C. Cartmell, D. M. Evans, J. M. L. Elwood, P. J. Murphy, et al., Toxicol in vitro., 2017, 44, 172-181.

Contact:

Email: ccartmell@upei.ca

Phone: 1-902-566-6064